I had problems with my sandisk pendrive since i used it for memtest. Since thene every time i connected it and then disconected it would still be present in my disk area untill i restarted my pc. But since today it stopped showing at all(maybe after windows 10 update?). I can see it in device manager as HDD, but cant do anything about it. Tried uninstall/install, on and off, tried to clean it with ntsf/fat32, but cant, because i get error that drive is not detected, etc. Works fine on other pc's.

try boot computer with ubuntu CD/DVD and try if pen drive Works on your computer
if Works fix OS or reinstall it
otherwise there is some problem with HW(motherboard, power supply)

First try to connect it to different pc or laptop and check whether it is working there or not.

Have you tried to change its drive letters and paths in disk management ? may be that help