Thanks for the extra details, although there's clearly something odd about the events with that docking unit, which is probably why I couldn't grasp the details before.

MrSpiffdifilous wrote:
The hotswap bay was/is a Thermaltake BlacX eSATA unit.
OK, and as I understand it, that docking station comes with its own small external PSU, and I presume that is the PSU which you were using.
MrSpiffdifilous wrote:
I tested several drives in it and for a while it worked well. Once I switched to the problem drives it started shutting off the unit. As soon as the drive was removed, the power came back. I took this to mean that it was working as intended.
That is the classic, expected behaviour when a drive with a shorted TVS (due to a previous prolonged overvoltage event) is attached to something with a small PSU. That small PSU will shutdown due to what it sees as an excessive load, due to that shorted (or, to be more accurate, low resistance) TVS diode.
MrSpiffdifilous wrote:
However, when I tested the drives that shut the unit down in the way we've been doing it 3 out of 4 ended up being fine.
Without detailed resistance measurements of the TVS diodes from those drives, and preferably seeing the drives & test stations in front of me, then I could only guess at the possible reason for that. IMHO that's an odd result.
MrSpiffdifilous wrote:
I'm not sure that I can get my hands on a DCO. [FYI, you mean DSO] I'm also not sure that if I were able to I'd know what I was doing. I'm more of a computer tech person than an electrical engineer.
Understood. Unfortunately TVS diode behaviour is an electrical (perhaps more specifically, electronic) engineering area.

That's where my primary qualifications are, but if that isn't your background then you may need to get someone else involved to assist with (and provide the equipment for) that measuring & troubleshooting -
unless my comments below apply, because something seems to be coming clearer, due to your recent update. If the below comments do apply, then investigating the PSUs may not need to be the priority.
MrSpiffdifilous wrote:
I've just been tasked with finding out whats going on here and determining if we are causing the issue or if the drives we're getting are just trash. I've removed serveral boards and found that the 12v TVS is cracked before testing.
A-ha! This is vital new info. I realised that we'd been focussing on the testing stations and burning TVSs there, but if the drives come to you with no "history", then you wouldn't know whether the TVS were already damaged (shorted / low resistance) unless you pre-screen them - hence why I mentioned this in my posting yesterday.
So as I understand it, there was no pre-screening for shorted TVSs being done, you were using high-wattage PSUs, and seeing burning PCBs during your testing. Therefore as I mentioned yesterday, one possibility is that the TVS diodes had already been damaged before you received the drives (and your mention of the cracked 12V TVS above confirms this, at least for that drive), and due to the high-wattage PSUs, they are much more likely to continue to supply power to a drive with a "shorted" TVS, which will always be a bad result.

Such a "shorted" TVS on the end of cables & connectors (which will have measurable resistance) is just like a heavy load, which is more likely to be within the capabilities of the power output from a high-wattage PSU. That is why your problems were reduced with lower-wattage PSUs, as you mentioned before.
MrSpiffdifilous wrote:
It's pretty easy to spot drives where this is the case as they smell very strong as soon as coming out of the ESD bags.
Understood, but you can't rely on a damaged TVS being that obvious. If the drive was previously (before the drive as sent to you) attached to a PSU which shutdown quickly, then the visible damage to the TVS can be minimal or none. I've seen "shorted" TVSs which look perfectly normal - they need to be measured (e.g. with a multimeter) to see that they have been damaged already by a previous overvoltage event.
Based on your comments, it seems possible that the original problem is that you're receiving drives which already have shorted TVS diodes; this condition isn't being screened first using a multimeter; then when power is applied from a PC PSU (even 250W model), the TVSs burn (as expected) due to those particular drive PCBs not having a fusible element to disconnect the power. That's more likely to happen with even higher-wattage PSUs, and the earlier suggestion from
SAjunky to use small (but good quality!) drive PSUs would be much less likely to be able to supply enough power for extensive PCB damage, compared with using PC PSUs.
However, IMHO your starting point must be to pre-screen (by measurement, not just visually) for any drives which would present an excessive load (this can be due to a shorted TVS diode or, rarer, another component which has failed and is now acting as a low resistance) on the main power rails.
Hope that helps.
